Search results for "Scale models"
showing 6 items of 6 documents
On the structural connectivity of large-scale models of brain networks at cellular level
2021
AbstractThe brain’s structural connectivity plays a fundamental role in determining how neuron networks generate, process, and transfer information within and between brain regions. The underlying mechanisms are extremely difficult to study experimentally and, in many cases, large-scale model networks are of great help. However, the implementation of these models relies on experimental findings that are often sparse and limited. Their predicting power ultimately depends on how closely a model’s connectivity represents the real system. Here we argue that the data-driven probabilistic rules, widely used to build neuronal network models, may not be appropriate to represent the dynamics of the …
Insights into the summer diurnal cycle over Eastern South Africa.
2018
Abstract Adopting a state-of-the-art numerical model system, we investigate how the diurnal variations in precipitation and local breeze systems are characterized by lower-boundary conditions related to the Drakensberg highland and warm SST associated with the Agulhas Current. A control simulation can simulate the hydrometeorological climates in the region realistically, but the terrestrial rainfall is overestimated. During daytime, the precipitation is confined to the Drakensberg highland, and there is an onshore local breeze, while during midnight to morning, the rainfall is confined to the Agulhas Current, and the breeze is offshore. These variations are captured by the numerical simulat…
A multiphase multiobjective dynamic genome-scale model shows different redox balancing among yeast species of the saccharomyces genus in fermentation
2021
Yeasts constitute over 1,500 species with great potential for biotechnology. Still, the yeast Saccharomyces cerevisiae dominates industrial applications, and many alternative physiological capabilities of lesser-known yeasts are not being fully exploited. While comparative genomics receives substantial attention, little is known about yeasts’ metabolic specificity in batch cultures. Here, we propose a multiphase multiobjective dynamic genome-scale model of yeast batch cultures that describes the uptake of carbon and nitrogen sources and the production of primary and secondary metabolites. The model integrates a specific metabolic reconstruction, based on the consensus Yeast8, and a kinetic …
The fractal model of non-local elasticity with long-range interactions
2010
The mechanically-based model of non-local elasticity with long-range interactions is framed, in this study, in a fractal mechanics context. Non-local interactions are modelled introducing long-range central body forces between non-adjacent volume elements of the elastic continuum. Such long-range interactions are modelled as proportional to the product of interacting volumes, to the relative displacements of the centroids and to a distance-decaying function that is monotonically-decreasing with the distance. The choice of the decaying function is a key aspect of the model and it has been proved that any continuous function, strictly positive, is thermodynamically consistent and it leads to …
Objective Bayesian point and region estimation in location-scale models.
2007
Point and region estimation may both be described as specific decision problems. In point estimation, the action space is the set of possible values of the quantity on interest; in region estimation, the action space is the set of its possible credible regions. Foundations dictate that the solution to these decision problems must depend on both the utility function and the prior distribution. Estimators intended for general use should surely be invariant under one-to-one transformations, and this requires the use of an invariant loss function; moreover, an objective solution requires the use of a prior which does not introduce subjective elements. The combined use of an invariant informatio…
Characterization of impervious layers using scale models and an inverse method
2009
We describe a novel procedure that uses an inverse method to determine unknown parameters for impervious layers used in multilayer structures. The proposed model of the multilayer structure is limited to an ideal double plate separated by an unbonded, fibrous, sound-absorbing material. Experimental data were obtained by nearfield acoustic holography for the calculation of the transmission loss of various multilayer structures mounted in a window in a wooden box designed specifically for this purpose. We used the Trochidis and Kalaroutis forecast model of acoustic insulation for multilayer structures, which is based on a spatial Fourier transform. The experimental pressure and velocity data …